Nndexrazoxane package insert pdf

The recommended tukysa dose reductions and dosage modifications for adverse reactions are provided in. Tepezza teprotumumabtrbw for injection, for intravenous use. Zinecard dexrazoxane for injection us package insert fda approved labeling for s006 110 1 2 zinecard 3 dexrazoxane for injection 4 5 6 description 7 8 zinecard dexrazoxane for injection is a sterile, pyrogenfree lyophilizate intended for 9 intravenous administration. Each 20 ml vial contains 200 mg of dacarbazine, usp active ingredient. Dexrazoxane is a cyclic derivative of edetic acid edta that readily penetrates cell membranes. Instructions for use duragesic durahgeezik fentanyl. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Chemically, dexrazoxane is s4,41methyl1,2ethanediylbis2,6piperazinedione. Using this hormone ring does not protect you or your partner against hiv or other sexually transmitted. Zinecard dexrazoxane dose, indications, adverse effects. See package insert addamel n is indicated in patients as a supplement in intravenous nutrition to meet basal to moderately increased requirements of trace elements. Drug manufacturers, package inserts, monographs flashcards. By continuing to browse this site you are agreeing to our use of cookies.

Dexrazoxane definition of dexrazoxane by medical dictionary. Dailymed dexrazoxane hydrochloride dexrazoxane kit. Totect dexrazoxane for injection totect package insert. Dexrazoxane for injection is a sterile, pyrogenfree iyophilizate intended for intravenous administration. The nuvaring is used to prevent conception pregnancy. Nitrostat is a stabilized sublingual compressed nitroglycerin tablet that contains. Dexrazoxane dex ray zox ane is used to protect against damage caused by certain chemotherapy. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication. Dexrazoxane for injection is available in the following strengths as sterile, pyrogenfree lyophilizates. Dexrazoxane also is used to repair tissue damage caused when. Save money on your ifosfamide injection prescription by switching to tevas fdaapproved generic version. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for trileptal oxcarbazepine.

Dexrazoxane is a whitish crystalline powder that melts at 191 to 197c. Myl today announced that its business mylan institutional has received final approval from the u. Teratogenic effects in the rat included imperforate anus, microphthalmia, and anophthalmia. It must neverbe given by the intramuscular or subcutaneous route. Dexrazoxane is converted intracellularly to a ringopened chelating agent.

The zinecard brand of dexrazoxane is used to help prevent chemotherapyrelated heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is prescribed to protect against damage caused by chemotherapy. For more information, please call 844 9897284 or visit eligible patients can register for valuable savings offers for nearly 40 brand name medications. Ndc 00872789 500 mg single dose vial with a blue fliptop seal, packaged in single vial packs. Highlights of prescribing information these highlights. Thus, it inhibits the lesions induced by subcutaneous s. Dexrazoxane is the name of the active ingredient in an intravenous iv drug administered to prevent the damage to the heart muscle that is associated with certain cancer chemotherapy drugs, called anthracyclines like doxorubicin. It is a cardioprotective agent for use in conjunction with doxorubicin. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for claritin loratadine. Important notice zinecard dexrazoxane for injection. Pdf good clinical and cost outcomes using dexrazoxane to.

Dailymed dacarbazine injection, powder, for solution. It is a cardioprotective agent for use in conjunction with. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose. Once reconstituted, the resultant solution contains 10 mg dexrazoxane per ml. Product information zyrtec name of the drug cetirizine hydrochloride description cetirizine hydrochloride is an orally active, h 1receptor antagonist. Saxenda liraglutide injection, for subcutaneous use. Dexrazoxane side effects, dosage, interactions drugs. Do not use a duragesic patch if the pouch seal is broken or the patch is cut, damaged or changed in any way. In animal reproduction studies, intravenous administration of dexrazoxane to pregnant rats and rabbits during organogenesis resulted in teratogenicity at maternal doses that were approximately 0. Dexrazoxane zinecard, totect is a prescription injectible drug used to prevent zinecard and treat totect specific side effects of some chemotherapy medications. Zinecard health care provider letter page 3 of 3 the reconstituted zinecard solution is intended for further dilution with lactated ringers injection, usp, to a concentration range of 1. Totect 500 mg dexrazoxane for injection each vial of dexrazoxane for injection contains 589 mg dexrazoxane hydrochloride. Dexrazoxane vial side effects by likelihood and severity.

Daunorubicin hydrochloride injection must be given into a rapidly flowing intravenous infusion. Zinecard dexrazoxane for injection description zinecard dexrazoxane for injection is a sterile, pyrogenfree lyophilizate intended for intravenous administration. Reduce zinecard dosage in patients with moderate to severe renal impairment creatinine clearance values less than 40 mlmin by 50% zinecard to doxorubicin ratio reduced to 5. Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications. Zinecard is a cytoprotective agent indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mgm 2 and who will continue to receive doxorubicin therapy to maintain tumor control. Dexrazoxane was toxic to pregnant rats at doses of 2 mgkg 180 the human dose on an mgm. If you have questions about this medicine talk to your doctor, pharmacist, or health care provider. The hydrolysis products of dexrazoxane are thought to exert their effects by chelating free or bound intracellular iron in the myocardium, thus preventing the formation of the.

Information for healthcare professionals on nitrostat nitroglycerin sublingual tablets, usp. Duragesic patches are available in different 6 dosage strengths and patch sizes. Download fulltext pdf good clinical and cost outcomes using dexrazoxane to treat accidental epirubicin extravasation article pdf available in journal of cancer research and therapeutics 64. Food and drug administration fda for its abbreviated new drug application anda for dexrazoxane for injection, packaged in 250 mg and 500 mg singleuse vials. Fda approved zinecard dexrazoxane for injection for full prescribing information. Cardioxane injection fda prescribing information, side. See 17 for patient counseling information and fda approved patient labeling. The woman should insert nuvaring on the first day of her menstrual bleeding. Nitroglycerin should be kept in the original glass container and must be tightly capped after. Determine if patients are taking drugs that could slow heart rate or atrioventricular conduction see warnings and. Nuvaring may also be started on days 25 of the womans cycle, but in this case a barrier method, such as male condoms with spermicide, should be used for the first seven days of nuvaring use in the first cycle. Recently, we have shown that dexrazoxane icrf187 is an effective antidote against accidental extravasation of anthracyclines. Prescribers and pharmacists must be alert to this difference in presentation in order to prevent medication errors. Severe local tissue necrosis will occur if there is extravasation during administration.

Hemlibra emicizumabkxwh injection, for subcutaneous use. A 250 mg singleuse vial of dexrazoxane should be reconstituted with 25 ml of sterile water for injection, usp. Selected from data included with permission and ed by first databank, inc. Dexrazoxane has an octanolwater partition coefficient of 0.

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